Genetic Test Kit (APOE Only)Description: The ApoE gene provides instructions for making a protein called apolipoprotein E. In the brain, ApoE is involved in clearing harmful plaques that form around nerve cells. These plaques are a hallmark of Alzheimers disease and consist of damaged proteins called amyloid which stick together to form the toxic plaques. There are at least three slightly different versions (alleles) of the ApoE gene. The major alleles are called E2, E3, and E4.