Life Extension, SAMe, S-Adenosyl-Methionine, 400 mg, 60 Enteric Coated TabletsSupports Joint and Emotional Well Being Dietary Supplement Enteric Coated Tablets Non GMO SAMe has multiple mechanisms of action that are used throughout the body Brain and Mood SAMe boosts brain cell methylation and facilitates youthful DNA enzymatic actions. These enzymatic actions are required for the healthy conversion of neurotransmitters such as norepinephrine, dopamine, and serotonin and may account for SAMe's mood elevating properties. SAMe