Semiprep/Preparative Guard Column, PRP-X300PRP X300 Overview Hamilton PRP X300 columns offer an easy, rapid way to separate closely related alcohols and organic acids. The sulfonated poly(styrenedivinylbenzene) support separates samples via a mixed mode mechanism. Separation on the PRP X300 is accomplished by three modes: hydrogen bonding, reversed phase, and ion exclusion. PRP X300 column selectivity can be altered by changing the pH of the buffer or adding an organic modifier (e. g.,
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